Abstract
BPA is present in canned goods and detectable in the urine of >95% of US adults. Studies suggest a link between BPA and cardiovascular disease, but mechanistic information in human subjects is extremely limited. We investigated whether consuming 12‐oz of canned soup daily for 5 days would impair flow‐mediated dilation (FMD) of the brachial artery. FMD is an assay of endothelial function that provides insight into cardiovascular health. Using a double‐blinded crossover design, we compared the effects of 5 days of canned vs. fresh soup consumption in 7 healthy adults. The fresh soup recipes were matched for sodium and fat content, but contained no canned ingredients. After each week of soup, urinary BPA and FMD (with B‐mode ultrasound using published guidelines) were measured. Data were compared using paired t tests. BPA was undetectable in fresh soup (<0.01 ug/ml), but was 0.98 ± 0.72 ug/ml in canned soup. Thus a 12‐oz portion of canned soup could be expected to contain approximately 350 ug of BPA (representing a concentration of 4.4 uM). After a week of fresh soup, urinary BPA was 1.61 ± 0.48 ug/L. In contrast, after a week of canned soup, urinary BPA increased to 5.85 ± 4.87 ug/L (p < 0.05). However, FMD did not differ following a week of canned or fresh soup (10 ± 4 vs. 8 ± 2%, p = NS). These preliminary findings indicate that acute BPA consumption has little or no effect on endothelial function in healthy young individuals.Grant Funding Source: Supported by T32HL090610 and AHA 11CRP7370056
Published Version
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