Abstract
The acute effects of the irreversible γ-aminobutyric acid (GABA) transaminase inhibitor, γ-vinyl GABA (Vigabatrin), were studied in the central nervous system of the rat. GABA concentrations were monitored in the hippocampus by implantation of microdialysis probes. Two doses of γ-vinyl GABA (1.6 and 8.0 mM) were administered via the probes and were found to cause a transient increase in the basal GABA outflow (10-fold) during the period of drug administration. In addition, γ-vinyl GABA pretreatment (1.6 mM) seemed to decrease K +-evoked GABA release (P < 0.05). The immediate increase of GABA outflow after γ-vinyl GABA administration may be the result of direct blockade of GABA uptake sites, a finding which further indicates that the action of GABA transaminase inhibitors may be mediated partly through GABA uptake inhibition.
Published Version
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