ACUTE CUTANEOUS TOXICITY AND IRRITANT EFFECTS OF IVERMECTIN FOR EXTERNAL USE IN WHITE RATS

Abstract

In All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" a prototype of a new drug form of Ivermectin was developed for cutaneous use against endo- and ectoparasites. The dosage form is a transparent solution for application to the skin with an Ivermectin content of 0.5%. For the experiment, 18 white male rats weighing 180-200 g were selected, which were divided into 2 experimental and one control group of 6 heads each. The coat of all animals was shaved on the back with an area of about 5x5 cm. The drug was applied at doses of 5 000 and 10 000 mg / kg, the control group did not receive the drug. The LD50 of the Ivermectin dosage form is more than 10 000 mg / kg, according to GOST 12.1.007-76 the drug belongs to the 4th class of danger when applied to the skin. The drug does not have an irritating effect when applied once to intact rat skin.