ОЦЕНКА ОСТРОЙ ПЕРОРАЛЬНОЙ ТОКСИЧНОСТИ И КУМУЛЯТИВНЫХ СВОЙСТВ ПРОТИВОПАРАЗИТАРНЫХ ПРЕПАРАТОВ ИНСАКАР ТОТАЛ С И ИНСАКАР ТОТАЛ К

Abstract

A wide range of antiparasitic medications is produced for treatment of parasitic diseases of domestic carnivores, but only few of them are highly effective. Recently, highly effective antiparasitic medications of a new generation were designed, including complex compositions of active substances. Our work presents results of tests of such composite antiparasitic medications as Insakar Total S and Insakar Total K, developed at Federal State Budgetary Scientific Institution "Federal Scientific Center - All-Russian Scientific Research Institute of Experimental Veterinary Medicine of the RAS. The ultimate advantage of these drugs is that they include a composition of active substances - imidacloprid, pyriproxyfen and moxidectin. The medications exhibit high antiparasitic activity against both ecto- and endoparasites. They have a destructive effect on imaginal and preimaginal stages of parasites. The parameters of acute toxicity of medications when administered into the stomach were studied. It was found that the half-lethal dose (LD50) of the medication for dogs was 4425 mg / kg. The LD 50 of the medication for cats was 4575 mg / kg. It indicates that the tested medications - "Insacar Total S" and "Insacar Total K" belong to the 3rd hazard class (moderately hazardous substances), according to the hygienic classification (State Standard GOST 12.1.007-76). The assessment of the cumulative properties of Insacar Total S and Insacar Total K was carried out. The cumulation coefficient of the tested medications was 2, it means that their cumulative properties are poorly exhibited.