Abstract
Abstract Background: Vancomycin-resistant Enterococcus faecium (VRE) is a low virulent pathogen. It can cause a variety of infections most commonly in immunosuppressed patients and those with previous exposure to broad-spectrum antibiotics. Case Presentation: A morbidly obese male with multiple comorbidities presented with acute cholecystitis. Because of the high operative risk it was decided to treat the condition with antibiotics and ultrasound-guided percutaneous cholecystostomy tube placement. Cultures of bile revealed VRE and initial therapy consisted of daptomycin. Cultures on day seven after initiation of daptomycin showed continuing growth of VRE and therapy was changed to linezolid and the patient was able to clear VRE from bile and cholecystitis resolved. The tube was removed after six months and interval cholecystectomy was planned after appropriate weight loss. Conclusions: We report the first case of VRE acute cholecystitis in North America. Only two additional cases have been reported thus f...
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