Abstract
Background: Clinacanthus nutans (C. nutans) Lindau (family Acanthaceae) is a shrub widely cultivated in the South East Asia region,
 including Malaysia. It has been traditionally used for treatment of various ailments including pain-mediated diseases. Various
 pharmacological activities of C. nutans have been reported except for its pain-relieving activity. This study was performed to evaluate the
 acute and sub-chronic oral toxicity of the methanol extract of Clinacanthus nutans (MECN) in male and female mice.
 Methods: In the acute toxicity study, a single dose of 5000 mg kg-1 of body weight MECN was administered orally, and was monitored
 for 14 consecutive days. In the sub-chronic toxicity study, the MECN was administered orally at doses of 50, 500, and 2500 mg kg-1 day-1
 for 28 days. Results: Results showed that there were no clinical signs of toxicity, mortality and body weight changes in both acute and
 subchronic toxicity studies. There were no significant differences in relative organ weight, haematological parameters, and biochemical
 parameters; except for the creatinine level, which indicated significant (p
Accepted Version (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call