Acute and Sub-Acute Oral Toxicity Profile of Purified Tomato Extract on the Liver and Kidney Functions of Male Wistar Rats

doi:10.26538/tjnpr/v5i11.12

Abstract

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Highlights

An acute toxicity testing is required to evaluate the adverse effects that might occur following the oral administration of a substance in single dose or multiple doses given within 24 hours
Acute toxicity testing of purified tomato extract The Wistar male rats were divided into two groups: a normal group that only received water and a group that was orally given Purified tomato extract (PTE) (750 mg/kg b.w.) once
The results showed that PTE caused no acute toxicity, and the estimated LD50 of the extract is above 750 mg/kg b.w

Summary

Introduction

An acute toxicity testing is required to evaluate the adverse effects that might occur following the oral administration of a substance in single dose or multiple doses given within 24 hours. The assay evaluates the risk of side effects after administering single or multiple doses of the test sample for 14-28 days.[1] Tomatoes are commonly used to make juice or pasta They provide a wide range of pharmacological benefits; including antioxidant, antihypercholesterol, and antidiabetic properties.[2] These pharmacological effects exist due to the presence of some phytochemical compounds in them. The sub-acute toxicity test is used to detect the toxic effect of a chemical that is given orally and repeatedly, for 28 days.[1] Sub-acute toxicity test provides information on the toxic effect on the affected target organs Both of these toxicity tests are required to observe the death of the test animals after being given pure tomato extract (PTE). The study was aimed at evaluating the acute and sub-acute toxicity effects of PTE on Wistar male rats

Materials and Methods

Results and Discussion

Conclusion