Abstract
Objective: to investigate the effectiveness of long-term oral administration of Actovegin in post-COVID patients with cognitive impairment (CI). Patients and methods . 444 patients (142 men, 302 women) with COVID-19 and CI participated in the study. One-half of the included participants – 222 patients (70 men and 152 women) – were prescribed with actovegin 400 mg 3 times a day in addition to the baseline therapy; 222 patients (72 men and 150 women) were randomized to the control group. Cognitive functions were assessed with Montreal Cognitive Assessment (Montreal Cognitive Assessment test, МоСA test), fatigue – with Multidimensional Fatigue Inventory (MFI-20), emotional disturbances – with Spielberger-Hanin test. Results and discussion . Post-COVID patients with CI in the Actovegin group after 60 days follow-up had higher mean MoCА scores (p<0.05), lower MFI (p<0.05), and Spielberger-Hanin test scores (p<0.05) compared to the control group. Conclusion. Positive effect of Actovegin on the cognitive functions and emotional state of post-COVID patients with CI was observed.
Highlights
Цель исследования – изучение эффективности длительного перорального приема Актовегина у пациентов с когнитивными нарушениями (КН), возникшими после перенесенной коронавирусной инфекции COVID-19
Patients and methods. 444 patients (142 men, 302 women) with COVID-19 and cognitive impairment (CI) participated in the study
Cognitive functions were assessed with Montreal Cognitive Assessment (Montreal Cognitive Assessment test, МоСA test), fatigue – with Multidimensional Fatigue Inventory (MFI-20), emotional disturbances – with Spielberger-Hanin test
Summary
Цель исследования – изучение эффективности длительного перорального приема Актовегина у пациентов с когнитивными нарушениями (КН), возникшими после перенесенной коронавирусной инфекции COVID-19. Применение Актовегина у пациентов с когнитивными нарушениями после перенесенной коронавирусной инфекции COVID-19.
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