A16984 Cognitive impairment and other target organs damage in patients with essential hypertension

Abstract

Objectives: To evaluate the relationship between cognitive function and damage of the target organs such as heart and kidneys in pts with essential hypertension (EH). Methods: Echocardiography were performed in 180 pts with EH (average age 51,5 ± 2,5; 70 females). We measured left ventricular mass index (LVMI). All patients underwent full clinical and laboratory screening evaluation. Kidney function was estimated by glomerular filtration rate (GFR) using the CKD-EPI creatinine equation. Cognitive function was assessed in all pts by Montreal cognitive assessment (MoCA) test. All patients were divided into 2 groups depending on the MoCA Results: group I (n = 101) – MoCA score ≥26, group II (n = 79) - MoCA score < 26. Results: Systolic (SBP) and diastolic (DBP) blood pressure were higher in patients with cognitive impairment, but this differences were not significant (SBP: 174,3 ± 6,2 mmHg – gr.II vs 166,2 ± 5,2 mmHg p > 0,05 – gr.I and DBP: 100,5 ± 4,7 mmHg vs 94,3 ± 4,1, p > 0,05 accordingly). Patients with MoCA score < 26 had significantly greater LVMI and lower GFR: pts of gr.I had LVMI 140,7 ± 8,2 g/m2 and GFR 80,3 ± 5,1 ml/min/1,73m2 vs pts of gr.II 156,9 ± 9,1 g/m2, and 63,3 ± 4,7 ml/min/1,73m2 accordingly (p < 0,05). GFR significantly correlated with MoCA results (r = 0,42, p < 0,05). Negative association existed between LVMI and MoCA test (r = − 0.48, p < 0,05). Adjustment for age, blood pressure, duration of hypertension, BMI and gender did not abolish this associations. Conclusion: there is relationship between cognitive function and severity of target organs damage in patients with essential hypertension: cognitive impairment increased with severity of heart and kidneys damage.