Activity of inflammation in patients with chronic obstructive pulmonary disease and anemia

Abstract

Patients with chronic obstructive pulmonary disease (COPD) in combination with anemia of chronic disease (ACD), are of particular interest to both scientific and practical health care. The purpose of the work - to study the activity of systemic inflammation.Material and methods. The results of the examination of 475 patients with exacerbation of COPD were analyzed, which were divided into two groups: group I - 155 people (61,3% men and 38,7% women) with ACD; group II - 320 patients (46,9% of men and 53,1% of women) without the anemic syndrome. Determination of the activity of the inflammatory process was performed by hemocytogram, serum markers of inflammation and integrated hematological indices. The results of the study. It was found that COPD in combination with ACD was accompanied by activation of the inflammatory process (erythrocyte sedimentation rate, segmented neutrophils content) and suppression of lymphocyte-monocyte inflammation, significantly higher integral hematological indices (leukocyte shift index; ratio of leukocytes, non-segmented neutrophils and all neutrophils to the erythrocyte sedimentation rate; the ratio of neutrophils to lymphocytes and the integrated index of inflammation), which increased with the deepening of the anemic syndrome, increasing patients age and was more pronounced in women. Activation of inflammation was associated with deterioration of bronchial patency according velocity parameters (Tiffno index, mean and peak volumetric velocities, maximal volumetric velocities by 25% and 75% of the forced ungs vital capacity). Anemic syndrome was also associated with higher levels of C-reactive protein (p>0,05), general fibrinogen (p<0,05) and seromucoids (p>0,05), the content of which varied in parallel with the leukocyte shift index. Conclusion. Anemic syndrome, as a manifestation of persistent systemic inflammation, worsens the course of a chronic obstructive pulmonary disease through affecting the respiratory function and the inflammatory process activation.