Abstract
Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ≤4 mg/liter. It had potent activity against extended-spectrum β-lactamase-positive Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species isolates. Amikacin, ceftazidime-avibactam, and meropenem had appreciable activity against non-CRE Enterobacteriaceae No comparators were active against multidrug-resistant P. aeruginosa isolates. Only trimethoprim-sulfamethoxazole had appreciable activity against S. maltophilia isolates. Overall, cefiderocol was associated with the lowest level of resistance.
Highlights
Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ⱕ4 mg/liter
We evaluated its activity against GNOs isolated exclusively from cancer patients
Whole-genome sequencing was done on the 12 isolates that were nonsusceptible to CFDC
Summary
Princea a Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA b. Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ⱕ4 mg/liter. -lactamase-positive Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species isolates. Ceftazidime-avibactam, and meropenem had appreciable activity against non-CRE. No comparators were active against multidrug-resistant P. aeruginosa isolates. Trimethoprim-sulfamethoxazole had appreciable activity against S. maltophilia isolates. Cefiderocol was associated with the lowest level of resistance
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