Abstract
Incubation in vitro of segments of hamster small intestine has been used to study the mode of absorption of myo- inositol . By all current criteria, myo- inositol is actively transported. We have observed accumulation against a concentration gradient, energy-dependence, Na +-dependence, phlorizin sensitivity, and saturation kinetics with a K m of 0.14 mM. Sugars which interact with and undergo the translocation step of glucose transport are non-competitive inhibitors of the transport of myo- inositol . myo- Inositol has no effect on the d-glucose transport system. Phlorizin interacts competitively with the myo- inositol binding site with an affinity 10–100-fold less than it has for the common sugar binding site. These results indicate that the pathway for myo- inositol to cross the brush border membrane is not entirely the same as the d-glucose pathway. However, they also indicate that there is an interaction between the two at the level of translocation.
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