Abstract
ObjectiveThe aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. MethodsBlood cDCs were enumerated for 34 SLE patients, defined as “active” (SLEDAI≥4) or “inactive” (SLEDAI<4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. ResultsThe frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. ConclusioncDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.
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