Abstract
This paper reports the results of a single case design pilot study of a music therapy intervention [the Active Music Engagement (AME)] for young children (age 3.51 to 4.53 years) undergoing hematopoietic stem cell transplantation (HCST) and their caregivers. The primary aims of the study were to determine feasibility/acceptability of the AME intervention protocol and data collection in the context of HCST. Secondary aims were to examine caregivers’ perceptions of the benefit of AME and whether there were changes in child and caregiver cortisol levels relative to the AME intervention. Results indicated that the AME could be implemented in this context and that data could be collected, though the collection of salivary cortisol may constitute an additional burden for families. Nevertheless, data that were collected suggest that families derive benefit from the AME, which underscores the need for devising innovative methods to understand the neurophysiological impacts of the AME.
Highlights
Hematopoietic stem cell transplantation (HSCT) is used to treat malignant conditions that require high dose chemotherapy, as well as non-malignant conditions such as hemoglobinopathies (Guilcher et al, 2018)
The fact that over a 4-month period 100% of eligible caregiver-child dyads agreed to participate in our study strongly suggests that HSCT is a high-risk treatment characterized by uncertainty and high symptom distress, caregivers of young children are willing to enroll and provide biological samples making it possible to recruit a sample of sufficient size for a sickle cell disease (SCD) study
This study investigated whether cortisol could be used as a stress biomarker in a SCD study to explore the effects of active music engagement (AME) on children undergoing HSCT, as well as their caregivers
Summary
Hematopoietic stem cell transplantation (HSCT) is used to treat malignant conditions that require high dose chemotherapy (and at times radiation therapy), as well as non-malignant conditions such as hemoglobinopathies (Guilcher et al, 2018). Cortisol as Biomarker in HSCT physical symptom distress, as well as diminished quality of life and family function (Kazak et al, 1997, 2005; Best et al, 2001; Santacroce, 2002; Kazak and Baxt, 2007; Ingerski et al, 2010; Graf et al, 2013; Virtue et al, 2014) This acute emotional distress is related to traumatic stress symptoms after treatment ends (Stuber et al, 1996, 1997; Kazak et al, 1998; Hobbie et al, 2000; Kangas et al, 2002; Bruce, 2006; Ingerski et al, 2010). In order to expand our understanding about how active music interventions work to mitigate transplant-related stress, we decided to explore the feasibility/acceptability of collecting cortisol (a stress biomarker) from children and caregivers
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