Activation of valvular interstitial cells and remodeling of extracellular matrix in calcific aortic valve stenosis

Abstract

Aim: Calcific aortic stenosis is the most common cause of aortic valve replacement in developed countries. The primary cell types in the aortic valve are valvular endothelial and interstitial cells (VICs). Abnormal aortic valve function likely results from extracellular matrix (ECM) remodeling associated with the disequilibrium between the synthesis of ECM components and their degradation.