Abstract
Activation of NF-kappaB differentially affects the proliferation rate of different non-small cell lung carcinoma cell lines
Highlights
Activity of NF-kappaB transcription factor is usually associated with stimulation of the proliferation potential of cancer cells
Expression analysis of target genes with qRT-PCR confirmed that H1299/RelA and H23/RelA cell lines maintained enhanced transcriptional activity of the exogenous RelA/p65
We found that RELA overexpression suppressed proliferation of the H1299 cell culture
Summary
Activation of NF-kappaB differentially affects the proliferation rate of different nonsmall cell lung carcinoma cell lines Activity of NF-kappaB transcription factor is usually associated with stimulation of the proliferation potential of cancer cells. Our research is aimed to dissect mechanisms behind the pro- and anti-proliferative effects of NF-kappaB in non-small cell lung carcinoma (NSCLC) cell lines. Methods: To avoid pleiotropic effects of extracellular stimuli, like TNF or EGF growth factors, we established NSCLC cell lines H1299 and H23 with constant overexpression of the RELA gene, which encodes the primary activation subunit of NF-kappaB.
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