Abstract
ATP increased the cytosolic Ca 2+ concentration ([Ca] i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca 2+ and Na +, and was blocked by voltage-dependent Ca 2+ channel blockers. The results suggest that the ATP-induced depolarization increases Ca 2+ influx via voltage-gated Ca 2+ channels resulting in the increase in [Ca] i.
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