Abstract
Raman probes based on alkyne or nitrile tags hold promise for highly multiplexed imaging. In order to functionalize the Raman probes to trace biological phenomena in live cells, we have established a general strategy to control Raman signal intensity based on the resonant Raman effect, and prepared activatable Raman probes that show enhanced Raman signals upon reaction with enzymes under physiological conditions. Recently, we expanded our molecular design strategy by developing aggregation-based Raman probes for detecting enzyme activities in tissues, photo-activatable Raman probes, and photo-switchable Raman probes for super-resolution Raman imaging.
Published Version
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