Actions of cimetidine and ranitidine at some cholinergic sites: Implications in toxicology and anesthesia

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Cimetidine and ranitidine are specific and potent H 2-receptor antagonists widely used in the effective therapy of peptic ulcer disease. The drugs also possess other pharmacological properties unrelated to H 2-receptor antagonism. More recently large experimental doses of cimetidine or ranitidine were found to have anti-cholinesterase, ganglion blocking and neuromuscular blocking activities. Actions of the drugs at such cholinergic sites may account for some of their clinically documented adverse effects. The toxicological implications of these findings including the potential for drug interactions to occur, especially during some anesthetic procedures, are discussed.