Abstract
1. 1. K +-induced and Ca 2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca 2+ modulatory activity. 2. 2. The Ca 2+ agonist BAY K8644 significantly enhanced Ca 2+-induced contractures while the Ca 2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca 2+ concentration range employed. 3. 3. At 10 −7 mol 1 −1 ABA had no significant effect on K +-induced or Ca 2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca 2+-induced contractures over the whole Ca 2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca 2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca 2+ entry blocking ability.
Published Version
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