Abstract
Summary Caerulein was tested for its stimulant activity on exocrine pancreatic secretion in twenty healty volunteers. The peptide strongly increased pancreatic secretion even at very low doses. Intravenous or intramuscolar administration of caerulein (0.1 and 0.75 μg/kg respectively) provoked a striking increase in volume and enzyme concentration which lasted more than 1 hr. Maximal i.v. doses of the peptide caused some discomfort in a few subjects whereas maximal i.m. doses did not. It is suggested that caerulein, which may offer some practical advantages over cholecystokinin-pancreozymin, may be useful in testing of pancreatic function in man with or without simultaneous administration of secretin.
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