Abstract
Studies on the inhibitory effects of a series of anti-snake-venom sera on the phospholipase A 2 activity of a number of snake venoms have been made using the suppression of phospholipase A 2 activity by the antiserum as an indicator of interaction between antibodies against phospholipase A 2 and snake venom phospholipase A 2. Specific antiserum against the venom of a particular species inhibited the phospholipase A 2 activity of the venoms of closely related species, but in most cases, failed to suppress phospholipase A 2 activity of venoms from other families. The amount of antiserum required for 50% inhibition of phospholipase A 2 activity varied with the species. The differences in the inhibitory properties of a particular antiserum on a heterologous phospholipase A 2 activity indicate variations in the antigenic sites of the enzyme molecule.
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