Abstract
In Rana ridibunda, the frequency of digit regeneration and the size of the new growths, which depend on the nature of the injured tissues, can be increased experimentally by injecting extracts from the scar epithelium. As in untreated digits, a blastema never forms and the scar epithelial extracts trigger the formation of chondrogenesis centers or stimulate their growth. Ordinary epidermis does not take part in this activity which is thus specific and seems to depend on proteolytic enzymes of the same type as collagenases. Anurans do not usually regenerate or if they do, it is in a rudimentary fashion; this is not due to the nonfunctional state of their scar epithelium, but rather to its insufficient activity and to the predominance of scar fibrous conjonctive tissue (fibroblastic) over chondroblastic tissue, the only type that can promote regeneration.[Journal translation]
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