Abstract
ACTINOMYCIN D is a potent inhibitor of RNA synthesis both in vitro and in vivo1,2. Its mode of action involves the intercalation with DNA at G-C regions and prevention of polymerase movement along the template3,4. Actinomycin D has also been shown to inhibit DNA synthesis, cell division and colony formation in mouse L cells5. We have studied the effects of this drug on the DNA of human KB cells in culture. Extensive DNA breakage was induced even at quite low concentrations of the drug.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
