Abstract
The purpose of the survey was to determine acute & chronic toxicity; in vivo antioxidant and anti-inflammatory actions of the different extracts of A. fraxinifolius Wight and Arn bark; along with estimation of the phenolic, flavonoidal contents and investigation of phenolic metabolites that may attribute to the activities. LD50 of the total ethanol extract (TEE) was 7.1 g/kg b. wt, the radical scavenging activity of DPPH showed 60.31% inhibition, FRAP ability and ABTS+ activity showed 55.024 and 67.217 µmol Trolox/100 g dry weight, respectively. TEE followed by ethyl acetate extract (EAE) at 100 mg/kg b.w exhibited the highest in vivo antioxidant activity (94.51% and 91.08% potency, respectively) compared with Vit E (100%). The TEE & EAE exhibited the highest anti-inflammatory activity (3.81±0.08 & 3.79±.0.04) respectively in comparison with indomethacin 3.83±0.01 measured as edema diameter after 4 hours of extract administration. The total phenolic and total flavonoid contents in the total ethanol extract (TEE) estimated as gallic acid and catechin equivalents were 61.06± 0.08 μg eq GA/g, 40.33± 0.20 μg CE/g extract respectively. EAE revealed five phenolic acids and eight flavonoid compounds isolated for the first time from the plant.
Highlights
A. fraxinifolius commonly known as mundane and shingle tree
In this work we propose to yield deep insight on the phytoconstituents of A. fraxinifolius bark as antioxidant& anti-inflammatory active agent
Thirty six male albino rats weighing 130-150g were divided into six groups, each of six animals, first group received 1 mL of saline serving as control, second to fifth group received 100 mg/kg of daily dose total ethanol extract (TEE), PEE, ChE, ethyl acetate extract (EAE) extracts respectively
Summary
A. fraxinifolius commonly known as mundane and shingle tree. It is a native spread around the world, especially in Africa and Asia (Vazquez et al 1987). Mundane, and lazcar are common names of A. fraxinifolius. It is well known that the bark of any plant provides protection of the tree, structural support, and leads nutrients from the leaves to the roots, it acts as a physical and chemical barrier against microorganisms, chemically the bark has the same constituents of wood such as terpenes, polyphenols, and nitrogen containing. Aisha Hussein Abou Zeid, Reda Sayed Mohammed, Amal Abdelrasheed Maamoun, Amany Ameen Sleem
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