Acquisition of new infection and clearance of type-specific human papillomavirus infections in female students in Busan, South Korea: a follow-up study

Jin-Kyoung Oh,Hai-Rim Shin,Wim Quint,Young-Hee Ju,Silvia Franceschi

doi:10.1186/1471-2334-8-13

Abstract

BackgroundLittle is known about the natural history of human papillomavirus (HPV) infection in Asian women.MethodsA follow-up study was conducted, with exfoliated cervicovaginal cells self-collected from, and questionnaires administered to 197 female students, aged 17–26 years, who had been already examined one and half years before. The presence of 25 HPV types was evaluated by a polymerase chain reaction-based assay.ResultsThe acquisition of new infection for any HPV type among 171 female students at risk who were negative at baseline, 60% of whom had remained as virgins, was 17.5% (95% confidence interval [CI]: 11.8–23.2). Among individual types, HPV16, 18 and 35 showed the highest rate of new infection. Women who had had first sexual intercourse (OR = 2.9; 95% CI: 1.0–8.8), or had changed sexual partners (OR = 2.9; 95% CI: 0.9–9.3) during the follow-up period showed a higher risk of new HPV infection than women who had remained virgins since baseline. The rate of new infection also tended to be higher in those who started, or continued smoking during the follow-up period, than in nonsmokers. Clearance of HPV infections since baseline examination was 80.6% (95% CI: 67.6–93.5), and did not differ between high-risk and low-risk HPV types or between single- and multiple-type infections.ConclusionThis study shows that the acquisition of new HPV infection among young women in the Republic of Korea is high and also the clearance is frequent. Self-collection of cervicovaginal cells is applicable to follow-up studies that include virgins.

Highlights

Little is known about the natural history of human papillomavirus (HPV) infection in Asian women
Among 197 students who participated in the follow-up study, 26 (13.2%) were positive for HPV DNA at baseline
Acquisition of new infections was highest for HPV 16, X, 18 and 35

Summary

Introduction

Little is known about the natural history of human papillomavirus (HPV) infection in Asian women. More than half of sexually active women worldwide are infected by one or more genital human papillomavirus (HPV) types at some point in time [1], and the three-year cumulative incidence of HPV infection among young women in some Western countries is over 40% [2,3,4]. HPV infection is very common, 50% to 77% of HPV-positive women in cohort studies have been shown to clear the infection spontaneously in one year's time [1,2,5,6,7,8]. No studies have investigated typespecific HPV incidence and clearance in Asian women. We followed up a group of female students in Busan, Republic of Korea, who had been evaluated for HPV prevalence one and a half years earlier [9]

Methods

Results

Discussion

Conclusion