Acquired Ocular Toxoplasmosis in a Patient with Sulfa Allergy-A Case Report

Abstract

Purpose: To report a rare case of acquired ocular toxoplasmosis in a patient with sulfa allergy.Method: A case report.Result: We report the case of a 55- year-old woman who presented with vitritis and focal chorioretinitis in right eye without a pre-existing scar. She had higher serum titers of anti-toxoplasma immunnoglobluin (Ig)M and IgG, leading to a diagnosis of acquired ocular toxoplasmosis. Because the patient had sulfa allergy, she underwent clindamycin therapy instead for 1 month, but the ocular lesion recurred. Subsequently, she underwent combination therapy with pyrimethamine, azithromycin, folic acid and corticosteroids for 1 month. The chorioretinal lesion reduced to a pigmented scar and the best corrected visual acuity of the right eye returned to 1.0 without recurrence of ocular lesions for 6 months.Conclusion: Acquired ocular toxoplasmosis is a rare disease. Laboratory tests for anti-toxoplasma antibodies can be useful in establishing diagnosis in such cases. Sulfadiazine can be successfully replaced by azithromycin in combination therapy for patients with sulfa allergy.