Abstract
Objective: Main objective is to study the solute solvent interactions in different heterocyclic drugs with the help of various acoustic properties. Method: The values of ultrasonic velocity are measured by using ultrasonic interferometer for solution of different concentrations of heterocyclic drugs (Lamivudine, Simvastatin) in 70% 1,4-dioxane as a solvent at 303.15 K. This experimental data is used to explore the acoustic properties like as intermolecular free length (Lf ), adiabatic compressibility (b s), apparent molal volume (ϕv), specific acoustic impedance (Z), apparent molal compressibility (ϕk), limiting apparent molal compressibility (ϕ0k ), limiting apparent molal volume (ϕ0v ), relative association (RA), solvation number (Sn) with respect to change in concentration. Finding : It is noticed that the solute solvent interaction between the heterocyclic drugs and dioxane systems are strong. Novelty: Heterocyclic drugs viz. Lamivudine and Simvastatin were used to study different acoustic properties. In present work the acoustic properties of Lamivudine and Simvastatin in 1,4-dioxane at 303.15K have been reported. Keywords: Lamivudine, Simvastatin, intermolecular free length, apparent molal volume, adiabatic compressibility, ultrasonic velocity.
Highlights
Interpretation of solute-solvent, ion-solvent interaction in non-aqueous and aqueous medium is done via measurements of the Ultrasonic velocity [1]
The acoustical properties of different drugs in methanol have been determined and the conclusion was drawn from adiabatic compressibility that the solvent methanol compress by four different drugs to the same extent but their solute-solvent interaction is different due to the difference in their size, shape and structure[3,4]
The ultrasonic velocity and density of amino acid in aqueous solution of magnesium acetate at constant temperature have been investigated [6], which indicates the ion-dipole interaction largely influenced by the size of ion and polarity of solvent
Summary
Interpretation of solute-solvent, ion-solvent interaction in non-aqueous and aqueous medium is done via measurements of the Ultrasonic velocity [1]. Ultrasonic studies may throw more light on the molecular interaction to know the behavior of solute and solvent molecules in liquid mixtures and solutions [2]. The acoustical properties of different drugs in methanol have been determined and the conclusion was drawn from adiabatic compressibility that the solvent methanol compress by four different drugs to the same extent but their solute-solvent interaction is different due to the difference in their size, shape and structure[3,4]. The different acoustical properties of some substituted Pyrazolines in acetone-water binary mixture have been determined [5] and it is observed that the ultrasonic velocity vary with concentration. The ultrasonic velocity and density of amino acid in aqueous solution of magnesium acetate at constant temperature have been investigated [6], which indicates the ion-dipole interaction largely influenced by the size of ion and polarity of solvent.
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