Acoustic Radiation Forces at the Crossroads of Ultrasound Exposimetry, HIFU, and Elastography.

Abstract

The applications of the acoustic radiation force (ARF) continue to multiply and extend from elastography into high-intensity focused ultrasound (HIFU), diagnostic imaging, lithotripsy, sonochemistry, levitation, and microsonics yet fundamental principles remain shrouded in mystery. A well-known and popular equation often used for calculating ARF in elastography is in conflict with the equation commonly employed for calculating ARF for determining acoustic power in radiation force balances (RFBs). Controversies have sparked debate for over a century concerning the physical mechanisms underlying ARFs. For over four decades, the science of ultrasound exposimetry has steadily improved and has provided clues in terms of accumulated data about the characteristics of transmitted ultrasound fields. Concurrently, the availability and capability of predicting these fields have improved significantly. The author draws on these sources to re-examine the physical principles behind ARFs. Conflicts are shown to stem from idealized configurations and simplistic assumptions. By more fully accounting for the pulse shape and spectrum, the effect of frequency power law attenuation, diffraction, and nonlinearity, more accurate equations are developed for ARFs for practical applications which are more consistent with exposimetry observations. Simulations compare well to corrected 1.5 MHz RFB data. While some questions await resolution, the approach presented here settles several longstanding conflicts and provides a new broadband framework for future ARF work.