Acoustic radiation force manipulation of tissue, cell, and interactions with neurons

Abstract

It is well known that an object in a sound field that absorbs, scatters, or reflects sound energy is subjected to the acoustic radiation force, and thus can be manipulated without contact. This unidirectional force has profound application in biomedicine. For example, the acoustic radiation force can be used to generate localized displacements in tissue, and the magnitude of the tissue displacement is inversely proportional to the local stiffness of the tissue. Based on this principle, the acoustic radiation force interaction with the tissue can be used for elasticity Imaging. The acoustic radiation force can also be used to manipulate cell’s movement and simulate isolated neuron, which may have potential application in tissue engineering and ultrasound neuro-modulation. In this study, our recent research on the application of the acoustic radiation force for manipulation of tissue, cell and interactions with neurons, will be presented. New approaches or systems for generation acoustic radiation force with special application will also be shown.