Acknowledging uterine angiolipoleiomyoma as a new diagnostic term: A proposal

Abstract

We are all familiar with the entity angiomyolipoma (AML), a benign mesenchymal neoplasm that most commonly occurs in the kidney with only a few cases reported in the uterus. Angiomyolipoma is composed of a variable mixture of adipose tissue, smooth muscle and anomalous blood vessels. While renal AML is often associated with tuberous sclerosis (TS) in around 5–80% of reported cases, there are also non-TS associated reported cases of AML. In addition to previous reported cases, we are also describing a uterine AML without history of TS and a negative HMB-45 immunohistochemistry. Taken together with the result of previous reported cases and a negative HMB-45 immunohistochemistry, we are proposing a new diagnostic terminology for the uterine lesions which are considered benign and are non-TS associated. We therefore propose the use of term ‘angiolipoleiomyoma’ for these uterine lesions.