Abstract
Background: Acinetobacter species is ubiquitous, aerobic gram-negative coccobacilli that are now emerging as an important nosocomial pathogen. Objectives: The present study was designed to know the prevalence of Acinetobacter in various clinical samples, their characterization and their antibiotic susceptibility pattern in B.P. Koirala Institute of Health and Sciences, Dharan. Methodology: Hundred Acinetobacter isolates obtained from different clinical specimens were taken. Identification to species level was done according to standard microbiological methods. Antimicrobial susceptibility to 10 antimicrobial agents was performed by Kirby Bauer method with special reference to Minimum inhibitory concentration to meropenem. Result : The predominant Acinetobacter isolate was Acinetobacter calcoaceticus (42%) followed by Acinetobacter baumannii (34%) , Acinetobacter lwoffii (18%) and Acinetobacter junii (6%). Resistance pattern to various drugs were Meropenem (19%), Piperacillin (96%), Piperacillintazobactum (43%) , Amikacin (51%), Ceftazidime (84%), Ceftriaxone (66%), Co-trimoxazole (58%), Gentamicin (57%), Ciprofloxacin (55%), Tetracycline (53%) . Eleven isolates of Acinetobacter were resistant to Meropenem as detected by MIC testing whereas resistant Acinetobacter by disc diffusion technique were 19 in number. Conclusion: Occurrence of Acinetobacter in our hospital as an important clinical isolate is a serious matter of concern. Moreover, its involvement in wide spectrum of diseases and development of resistance to commonly used antimicrobials has further worsened the situation. Prudent use of antimicrobials, effective surveillance of antimicrobial resistance and adherence to infection control practices, perhaps are the key factors that may prevent the development and dissemination of resistance among the local isolates. Journal of Nobel Medical College Vol. 2, No.1 Issue 3 Nov.-April 2013 Page 43-48 DOI: http://dx.doi.org/10.3126/jonmc.v2i1.7675
Highlights
Members of the genus Acinetobacter have been implicated in a wide spectrum of infectious diseases
Result : The predominant Acinetobacter isolate was Acinetobacter calcoaceticus (42%) followed by Acinetobacter baumannii (34%), Acinetobacter lwoffii (18%) and Acinetobacter junii (6%)
Occurrence of Acinetobacter in our hospital as an important clinical isolate is a serious matter of concern
Summary
Members of the genus Acinetobacter have been implicated in a wide spectrum of infectious diseases. Associated primarily with nosocomial infection, it has been involved in cases of community acquired infection.[1] Acinetobacter causes mild to severe illness. The number of nosocomial infections caused by Acinetobacter species has increased in recent years and is of increasing concern in critically ill patients and the risk factors for this infection are not well established.[2] Its ubiquitous presence, survival ability and rapid development of resistance to the commonly used antimicrobials are responsible for emergence of this organism as a significant nosocomial and opportunistic pathogen. 3. Journal of Nobel Medical College Vol 2, No.[1] Issue 3. Acinetobacter species is ubiquitous, aerobic gram-negative coccobacilli that are emerging as an important nosocomial pathogen
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
