Abstract
This study was designed to investigate gastric acid secretion and electrolyte composition in diabetic rats. 60 male rats of Wister strain weighing between 200 – 260g were used for the study. Diabetes was induced with 65mg/kgbw alloxan intravenously and confirmed with a constant blood glucose level ≥200mg/dl. Acid secretion was measured using the continuous perfusion method. Gastric juice was collected through a duodenal cannular attached to the pyloric ligation and its electrolyte composition was determined. Basal acid secretion was collected in aliquots every 10minutes for a period of 50minutes Histamine (10mg/kgbw) was injected intramuscularly into the histamine group and carbachol (20μg/kgbw) was injected intramuscularly into the carbachol group tostimulate acid secretion. Stimulated acid secretion was collected for 50 minutes at 10 minutes interval. There were significant reductions (p
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