Abstract
The acid mucopolysaccharide content, composition and molecular weight distribution in cortex, medulla and papilla of kidneys from normal subjects and from one patient each with mucopolysaccharidosis type I (Hurler) and type II (Hunter) were determined. It was found that heparitin sulfate and hyaluronic acid were the major acid mucopolysaccharides in normal human kidneys, the former predominating in the cortex and the latter in the medulla and papilla. The total amount of acid mucopolysaccharides in the kidneys from the patients with mucopolysaccharidoses was more than ten times higher than in the unaffected controls. In addition, there was an increase of 15- to 50-fold in the dermatan sulfate, and of 3- to 5-fold in the heparin sulfate content and a drastic shift in the molecular weight distribution towards smaller molecules.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call