Abstract
1. 1. The content and fractional distribution of acid mucopolysaccharides in normal human-heart valves were studied. 2. 2. The acid mucopolysaccharide content was significantly different in the aortic, mitral and tricuspid valves in the young age group. The aortic valve contained the highest amount of acid mucopolysaccharide and the tricuspid had the least. 3. 3. The content of acid mucopolysaccharide decreased with age in these three valves. The decrease was most marked in the aortic valve and the tricuspid showed the least change. 4. 4. Three kinds of acid mucopolysaccharide, namely hyaluronic acid, chondroitin sulfate B and chondroitin sulfate A or C were found in these valves. Hyaluronic acid was the major component constituting approx. 60% of the total acid mucopolysaccharide. 5. 5. There was no remarkable change in the distribution of these three acid mucopolysaccharides during the aging process from 20 to 60 years or over.
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