Abstract
The acid-base properties of cefalosporines, such as cefalotin, cefazoline, and cefalexin, were studied. The concentration constants of their acid dissociation at 20°C on the background of 0.1, 0.4, 0.7, and 1.0 M solutions of KCl and KNO3 were determined. Thermodynamic dissociation constants were calculated. The semiempirical PM3 quantum-chemical method was used to calculate the size of the ionic forms of the cefalosporines in the energetically preferred conformations.
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