Abstract
Acid-base properties were studied by means of pH-metry. The concentration acid dissociation constants of the carboxy, ammonium, and phenolic groups (20°C, on the background of 0.1, 0.4, 0.7, and 1.0 M solutions of KCl and KNO3) were determined. Semiempirical quanum-chemical calculations by the PM3 method were used to calculate the sizes of ionic forms of amoxycillin in energetically favorable conformations. Thermodynamic dissociation constants were obtained by extrapolation of the concentration constants to zero ionic strength according to the Huckel equation with inclusion of the calculated ionic sizes.
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