Abstract
In the current study, we synthesized silver nanoparticles (AgNPs) using Achillea wilhelmsii C. Koch (Aw) aqueous extract and evaluated their blood-compatibility and potential application in wound healing. Aw-AgNPs were synthesized by exposure to sunlight irradiation and then characterized by UV–vis spectroscopy, FT-IR (Fourier transform infrared), XRD (X-ray diffraction), and TEM (Transmission electron microscopy). Their potential application for wound healing was assessed by in vitro evaluation of antioxidant, antimicrobial, and clotting time. Their blood-compatibility was evaluated by hemolysis. Our results indicate spherical AW-AgNPs with an average particle size of 16.86 ± 4 nm. Aw-AgNPs with 62.7 % oxidation inhibition at a concentration of 350 μg/mL showed better antioxidant capacity than that of Aw extract. Excellent antimicrobial activity of Aw-AgNPs was obtained against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans fungus. Besides, Aw-Ag NPs at concentrations of 0.5 and 1 mg/mL reduced clotting time up to 3 min. According to the hemolytic assay, Aw-AgNPs are hemocompatible and have minimal effect on erythrocyte cells even at the highest concentration. In conclusion, blood-compatible Aw-AgNPs with antioxidant, antibacterial, and antifungal properties, and unique feature of reducing clotting time can be applied in wound healing.
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