Abstract
The present work describes the effect produced by phenylacetic acid, phenylethylacetic and diphenylacetic acids (sodium salts) separated and together with vanadyl sulfate on some “indices,” of acetylcholine metabolism in the rat's brain. Total cholinesterase activity and the “free” and “bound” (conditionally) acetylcholine levels served as indices. As shown experimentally the use of phenylacetic acid derivatives is accompanied by reduction of the “bound” acetylcholine, content, whereas that of “free” acetylcholine and the total tissue cholinesterase activity remain unchanged. Vanadyl sulfate provokes a significant reduction of the total tissue cholinesterasic activity, but does not change the content of “free” and “bound” acetylcholine therein. In conjoint action of the above-mentioned substances, the effects of phenylacetic acid erivatives are supplemented by the anticholinesterase effect of vanadyl sulfate.
Published Version
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