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Abstract
The fiber-optics-based Mueller matrix polarization sensitive optical coherence tomography (PSOCT) can measure the complete depth-resolved Mueller matrices of biological samples and is a choice for practical clinical applications. To quantitatively interpret the measurement results, the system errors and the detection noise in a fiber-optics-based PSOCT are analyzed, simulated and eliminated. The depth-resolved polarization parameter images of the skin of inflamed and healthy mice are presented to demonstrate that the system has the capability of accurately differentiating between normal and diseased tissues. In addition, the values of the polarization parameters after removing the noise and their changes with depth may be helpful quantitative diagnosis of the diseases and the evaluation of the treatment.
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