Abstract
After a single i.p. dose to rats, chlorpromazine, fluphenazine, promazine, triflupromazine and trimeprazine achieve brain/plasma ratios > 1, with half-lives in brain and plasma of < 10 hr. After five doses at 12-hr intervals, brain/plasma ratios of all compounds, except triflupromazine, are greater than after a single dose, due to accumulation in the brain. Triflupromazine appears to reach a maximum limit in the brain at about 11–12 μg/g. The half-lives of promazine and trimeprazine in brain and plasma are greater after five doses than after a single dose, while those of chlorpromazine, fluphenazine and triflupromazine are essentially the same after one or five doses.
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