Abstract
A total of 88 specimens of hepatocellular carcinoma (HCC) and its surrounding liver tissues were studied to assess the role of a mutant p53 protein in HCC. The mutant p53 protein was evaluated by an immunoperoxidase detection system. Mutant p53 protein was detected in 46.6% of HCC specimens, and in 70.6% of surrounding liver tissues. A statistically significant association was found between the elevation of serum AFP and the accumulation of mutant p53 in HCCs (P<0.05), and in surrounding liver tissues (P<0.005). These results imply that mutant p53 protein may function as a regulatory factor in the transcription of the AFP gene during development of HCC.
Published Version
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