Abstract
Accumulation of metabolic side products might favor the production of ethanol in Pho13 knockout strains.
Highlights
In a paper recently published in Nature Chemical Biology [2], we describe the discovery of a striking example illustrating the metabolite repair concept
We found that a single phosphatase serves to destroy three side-products of glycolysis, 4-P-erythronate, 2-P-glycolate and L-2-Plactate (Fig. 1)
This presumably explains the low level of fructose-2,6bisphosphate and low glycolytic flux observed in P-glycolate phosphatase (PGP)-KO cells
Summary
In a paper recently published in Nature Chemical Biology [2], we describe the discovery of a striking example illustrating the metabolite repair concept. We found that a single phosphatase serves to destroy three side-products of glycolysis, 4-P-erythronate, 2-P-glycolate and L-2-Plactate (Fig. 1).
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