Accumulated ecological damage to the health of workers in the production of vinyl chloride

Abstract

With prolonged exposure of workers in the production of VC to adverse factors, an increase in immunity stress (over time after 5 years) in healthy workers and an imbalance in the system of pro-anti-inflammatory cytokines in individuals with initial manifestations of neurointoxication with VC were recorded. Reduction in the degree of manifestation of compensatory and protective reactions that do not allow for the full implementation of protective mechanisms under the continuing chronic exposure to VC, contributes to the accumulation of ecological damage to the health of workers. The results obtained necessitate the timely detection of initial functional changes, indicate high informative value of biomarkers (IL-1β, TNFα, INFγ, IL-4, S-100, NF-200, MBP) and the possibility of using them to monitor the degree of manifestation of the pathological process. Identification of the leading immunopathogenetic factors of neurological deficit increase can be the basis for developing a method for predicting the individual risk of developing occupational neurointoxication.