Abstract
AbstractThis study reports the first synthesis of tetrahydroquinaldic and tetrahydropicolinic amides using readily available quinolines and pyridines through dearomative difunctionalization and hydrolysis under transitionâmetalâ and reductantâfree conditions. The prepared amide products could be easily oxidized to the corresponding quinaldic and picolinic amides. Furthermore, the chemical reactivity of the amide group has been explored to develop convenient methods for their conversion to other common organic functional groups.
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