Abstract
The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.
Highlights
The biggest problem of drug-based therapy is selectivity because of side effects that can be dose-limiting
After this modified pulse sequence, the standard pulse program with 16 scan was used to record the spectra for the analysis of the hydrolysis
The alternating magnetic field is technically realized as a magnetic gradient, a typical equipment of all modern NMR systems (400 MHz Bruker Avance spectrometer, alternating gradient frequency = 3 kHz, gradient amplitude ?/-10% from maximal 55 Gauss/cm)
Summary
The biggest problem of drug-based therapy is selectivity because of side effects that can be dose-limiting. Keywords Gold nanoparticle Á Magnetic field Á Relaxation Á Hydrolysis Á Pro-drug
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