Abstract
BackgroundThere is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy.MethodsThe influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands.ResultsThe magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. We also observed a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure 24 hrs after the MNPs injection.ConclusionsThese results indicate that intratumoral administration of surface modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, we have found that after intravenous administration of micromolar concentrations, these MNPs are capable of causing an anti-tumor effect in a mouse melanoma model after only a short AMF exposure time. This is a clear improvement to state of the art.
Highlights
There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy
This was achieved employing a Philips CM-200 TEM instrument operating at 100 kV. 1-2 micrograms of the Methods: The influence of bimagnetic nanoparticles (MNPs) were dissolved in anhydrous tetrahydrofuran THF (5 mL) and one drop of the resulting nanoparticle solution was spread over a copper grid (300 mesh size) supporting a thin film of amorphous carbon
Cytotoxicity of Magnetic Nanoparticles on B16-F10 cells MNP toxicity was tested after overnight incubation of B16-F10 cell cultures in 24-well plates with various MNPs concentrations, as measured by iron concentration
Summary
There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. Many biological processes feature alternate pathways which can be upregulated, if needed, thwarting molecularly targeted therapies [1]. To overcome these obstacles, a successful cancer therapy has to combine several approaches. Molecular targeting can be a viable component of this methodology Other approaches, such as stem cell delivery, hyperthermia, photodynamic therapy, and the design of multifunctional platforms that combine cancer diagnostics and treatment (theranostics) have not received full attention during the last decade
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