Abstracts and Case Studies From the College of American Pathologists 2024 Annual Meeting (CAP24)

The Abstracts and Case Study Program is a competitive program sponsored by the Education Division of the College of American Pathologists (CAP). The program is designed to promote a broad range of research in pathology. It offers CAP junior members the opportunity to submit original research or unique case studies to their peers in a poster presentation format. Submissions to this program are evaluated by a juried panel. CAP junior members are eligible for cash awards for their presentations. The Abstracts and Case Study Program also provides a unique opportunity for residents to enhance research skills, develop writing proficiency, gain practical experience at presenting their findings, and contribute to the literature and advancement of pathology. Abstract and case study poster sessions were conducted at the CAP's Annual Meeting on September 11–13, 2005, in Chicago, Ill.

Symposium 18: Citizen Science in Ecology: the Intersection of Research and Education

Introduction: Annual scientific meetings are intended in part to provide initial dissemination of research findings directly to meeting participants. However, the eventual publication of research findings is important for dissemination to the broader medical and scientific communities. The Limb Lengthening and Reconstruction Society: ASAMI–North America (LLRS) annual meetings showcase important research and case studies in the field of limb reconstruction pertinent to an international community of surgeons. The purpose of this analysis is to determine the publication rates of abstracts from recent LLRS annual meetings. Materials and Methods: Annual meeting programs from six LLRS annual meetings from 2014 to 2021 were cataloged. Listed abstract titles and authors were then queried in PubMed, Google Scholar, and the Journal of Limb Lengthen and Reconstruction to determine if a corresponding work was published journal up to December 2022 and time to publication. Results: During all studied annual meetings, 249 abstracts were presented. By December 2022, 60% (161/269) were published. The longest time to publication was 6 years following the presented annual meeting, whereas the meantime to publication was 21 months. The top publishing journals were the Journal of Pediatric Orthopaedics, the Journal of Limb Lengthening and Reconstruction, and Strategies in Trauma and Limb Reconstruction. Discussion: The LLRS annual meeting abstracts lead to a corresponding publication at rates revealing other orthopedic subspecialty societies. However, there are opportunities to improve these rates by continuing to promote the LLRS partnering journals including the Journal of Limb Lengthening and Reconstruction.

Update on MTM

Objective: There is a disproportionately higher burden of cancer among racial and ethnic minorities, with the incidence only expected to increase significantly by 2050. These racial differences may be due to the quality of early detection screening among this population. The purpose of this research is to provide case study reports about cancer screening practices among at-risk populations as well as those from underrepresented racial and ethnic minority backgrounds as well as sexual and gender minorities in order to describe disparities in cancer screening practices. These five case studies reveal how racial disparities vary by cancer site. These case studies will share information about current cancer prevalence, current recommendations for cancer prevention, national guidelines about early detection for lung, colorectal, prostate, cervical and breast cancers, as well as discuss ways to reduce cancer health disparities and improve screening practices. Methods: Data sources for these case studies include research reports, literature review, clinically-based articles, research articles, websites, as well as clinical practice observations and experiences. Research Summary: These case studies contribute to the growing body of knowledge related to cancer health disparities, with a special emphasis on cancer screening behaviors among underrepresented, at-risk, and racial and ethnic minority backgrounds. Since cancer care is multidisciplinary, these case reports also highlight the role of oncology nurses in helping to lead in educating, promoting, and bringing awareness to cancer screening recommendations and current cancer prevention guidelines for individuals and their families. Nurses recognize that one of the biggest barriers to screening is when individual have unrelated health care priorities that overshadow priorities related to screening, such as food, shelter, and safety. Nurses are also positioned to provide cancer-specific screening guidelines and resources to help individuals implement these recommendations into their daily lives. Improving screening rates among minority populations requires collaborations with the health care systems and the community. Conclusion: Evidence indicates that there are significant disparities that exist in cancer screening practices among minority populations as well as disproportionately higher cancer mortality rates in these populations. Barriers to screening include lack of access to high-quality health care, lack of health insurance, transportation issues, fear and lack of trust in the health care team, embarrassment, stigma related to sexual orientation or gender identity, discrimination in quality care and treatment, as well as lack of awareness about screening recommendations. Recognition of barriers to screening among minority populations is critical to developing targeted interventions that promote adherence and decrease risks of cancer-related mortality. Citation Format: Tamryn F. Gray, Joycelyn Cudjoe, Hae Ra Han, Jennifer Wenzel, Roland Thorpe, Jeanne Murphy. Have you checked? Disparities in cancer screening practices among minority populations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5293. doi:10.1158/1538-7445.AM2017-5293

Background: Anaplastic astrocytomas WHO III° (AA) represent diffusely infiltrating, high grade gliomas (HGG). Despite advancements in the molecular characterization of HGG treatment options are limited and are often in analogy to grade IV glioblastoma treatment. Tumor Treating Fields therapy (TTF) is an established modality for newly diagnosed and recurrent glioblastoma (GBM) shown to significantly improve progression-free and overall survival. While TTF is under investigation in grade III gliomas in several clinical trials, we present an exemplary case of an AA undergoing mid-term TTF therapy and adjuvant chemotherapy to explore treatment adherence, feasibility and safety. Methods: We present case details of a patient from our specialized neurosurgical oncology center, with an anaplastic astrocytoma (WHO grade III) who began TTF treatment at first diagnosis while being in the adjuvant chemotherapy phase at the time of TTF commencement. We describe treatment details and the course of disease under continuous and ongoing TTF therapy. Results: In December 2016 a 43year-old male patient was diagnosed with an anaplastic astrocytomaIDH 1/2 mutant, MGMT promoter-hypermethylation without 1p/19q codeletion. After biopsy and consequent partial tumor resection, he received concomitant radiochemotherapy and adjuvant chemotherapy with temozolomide. TTF was started six months after initial diagnosis. He has now completed 1328 days of treatment with an average daily usage of 90% and has survived 48 months from first diagnosis (cutoff January, 8th, 2021). Since beginning TTF, he has undergone temozolomide treatment for 6 cycles. He continues TTF without further adjuvant therapy. The patient is symptomatically stable and his quality of life is maintained. Significant adverse events or longer treatment interruptions have not occurred. Conclusion: The treatment with TTFields was well tolerated and seems to be feasible in this patient with an anaplastic astrocytoma. Considering the long treatment duration and favorable average daily usage, this treatment might be suitable for a long-term treatment in high grade gliomas. Ongoing clinical trials will provide more information on safety and efficacy for the use of TTFields in patients with grade III gliomas. Citation Format: Darko Markovic. Long-term application of TTFields in anaplastic astrocytoma - a case study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB064.

Background: Patient navigation for breast cancer seeks to diminish social, economic, cultural and medical system barriers to timely quality care. In the context of unmet patient needs, growing complexity of health care delivery systems, and significant local implementation challenges, patient navigation models must continue to evolve in order to advance context-appropriate implementation and sustainment of patient navigation into routine practice. We present five case studies in Chicago demonstrating evolving patient navigation models and in each case study, we explore challenges and opportunities related to advancing successful implementation of patient navigation interventions across the breast cancer care continuum. Methods: Case studies include: (1) a community-level adaptation of patient navigation in Chicago's Chinatown; (2) a community navigation program in Chicago's racially/ethnically diverse North Lawndale and Humboldt Park; (3) a county-wide dissemination of navigation in suburban DuPage County; (4) a state-wide scaling of a patient navigation model to the Illinois Department of Health and Family Services; and (5) a 4R patient navigation oncology model (4R = Right Information / Care / Patient / Time) grounded in systems engineering and design that leverages collaborative care plans and iterative examination and improvement of processes to address challenges of breast cancer care planning, team-based delivery and patient engagement. Results: Case studies in the evolution of patient navigation research programs show how identified gaps in care were remedied pragmatically in the course of each study. We show how patient navigation implementation efforts have been aided with evolving models incorporating the local implementation context, characteristics of program implementers, and structural, macro-level factors involving care delivery systems and public policy. Results highlight approaches for supporting organizational learning to enhance implementation and sustainability of navigation interventions; for furthering task clarification and coordination to optimize integration of patient navigation into cancer care delivery settings; and for tackling the impact of existing local, state, and national policy initiatives on patient navigation. Conclusions: Reducing breast cancer burden, especially among underserved populations, warrants adaptive, ongoing improvement of patient navigation models. Through iterative intervention development, evaluation, and refinement, patient navigation can move beyond serving as a temporary bandage for health systems fragmentation and toward an essential role in systems change for optimizing cancer care delivery. Citation Format: Melissa A. Simon, Laura S. Tom, Julia R. Trosman, Christine B. Weldon, Catherine A. O'Brian, Marcie C. Kirschner, XinQi Dong. The evolution of patient navigation research models to reduce breast cancer disparities: Case studies of patient navigation dissemination and implementation in Chicago [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1637.

s, A21. Rogno, H., Kristensen, A., and Amundsen, L. [1999] The Statfjord 3D, 4C OBC survey. The Leading Edge, 18(11) 1301-1305. Rosland, B.O., Tree, E.L. and Barkved, O.I. [1999] Acquistion of 3D/4C OBS data at Valhall. 61st EAGE Conferecence and Exhibition, Expanded Abstracts, 6-17. Stewart, J., Shatilo, A., Jing, C., Rape, T., Duren, R., Lewallen, K., and Szurek, G. [2004] A comparison of streamer and OBC seismic data at Beryl Alpha field, UK North Sea. 74 Ann. Internat. Mtg., Soc. of Expl. Geophys. Stewart, S.A. and Davies, R.J. [2006] Structure and emplacement of mud volcano systems in the South Caspian Basin. AAPG Bulletin, v90, 771-786. 4269 SEG Houston 2009 International Exposition and Annual Meeting EDITED REFERENCES Note: This reference list is a copy-edited version of the reference list submitted by the author. Reference lists for the 2009 SEG Technical Program Expanded Abstracts have been copy edited so that references provided with the online metadata for each paper will achieve a high degree of linking to cited sources that appear on the Web. REFERENCES Barkved, O. I, A. G. Baerheim, D. J. Howe, J. H. Kommedal, and G. Nicol, 2003, Life of field seismic implementation — First at Valhall: 65th Annual Conference and Exhibition, EAGE, Extended Abstracts, G055. Berg, E., B. Svenning, and J. Martin, 1994, SUMIC — A new strategic tool for exploration and reservoir mapping: Journal of Applied Geophysics, 34, no. 2, 139–140. Bouska, J., and R. Johnston, 2005, The first 3D/4-C ocean bottom seismic surveys in the Caspian Sea: Acquisition design and processing strategy: The Leading Edge, 24, no. 9, 910–921. Howie, J., N. Robinson, M. Riviere, T. Lyon, and D. Manely, 2005, Developing the long-term seismic strategy for Azeri-Chirag- Gunashli, South Caspian Sea, Azerbaijan: The Leading Edge, 24, no. 9, 934–939. Johnston, R., J. Bouska, T. Lyon, A. Ashby, R. Walters, P. Whitfield, P. Crompton, D. Ebrom, M. Mueller, and L. Thomsen, 2004, Azeri 4C: Processing the first 3D OBS survey in the Caspian Sea: 74th Annual International Meeting, SEG, Expanded Abstracts, 841–844. Johnston, R., S. Linn, D. Baptiste, and E. Kjos, 2005a, The maturity of ocean-bottom seismic: An example from Trinidad: 67th Conference and Exhibition, EAGE, Extended Abstracts, P073. Johnston, R., J. Bouska, T. Lyon, and D. Manley, 2005b, Benefits of 3D 4C surveys in the Caspian Sea: EAGE/SEG Research Workshop, Extended Abstracts, A26. Johnston, R., D. Buddery, N. Davis, P. Albertus, F. Estella, Y. Supriyatna, and D. Samsu, 2007, Indonesian Ocean-Bottom Seismic using a seabed plough: An industry first: Journal of Applied Geophysics, 54, 297–318. Johnston, R., and P. Paramo, 2008, Converted-wave imaging in the Caspian Sea: A view of mud volcanoes: 70th Annual Conference and Exhibition, EAGE, Extended Abstracts, B009. Li, X. Y., and J. Yuan, 2003, Converted-wave moveout and conversion-point equations in layered VTI media revisited: Theory and applications: Journal of Applied Geophysics, 54, 297–318. Luke, E., J. Bouska, A. Ashby, R. Johnston, and T. Probert, 2005, PS multi-component processing over a mud volcano in the Caspian Sea: 75th Annual International Meeting, SEG, Expanded Abstracts, 939–942. Lyon, T., J. Bouska, R. Johnston, M. Mueller, and L. Thomsen, 2004, Reducing structural uncertainty on the Azeri field using Ocean Bottom Seismic: Offshore Azerbaijan: The Leading Edge, 24, no. 9, 910–921. Manley, D., S. F. Mohammed, and N. D. Robinson, 2005, Structural interpretation of the deepwater Gunashli Field facilitated by 4-C OBS seismic data: The Leading Edge, 24, 922–926. McGarrity, J., T. Berg, S. Fowler, M. Ibram, and L. Wang, 2009, Improving C-wave imaging — A case study from the Clair OBC data: 71st Annual Conference and Exhibition, EAGE, Extended Abstracts, X028. Nolte, B., 2005, Converted-wave migration for VTI media using Fourier finite-difference depth extrapolation: 67th Annual Conference and Exhibition, EAGE, Extended Abstracts, P001. Rape, T. D., A. Shatilo, X. G. Li, S. Oppert, K. Lewallen, D. Coney, and K. Espejord, 2005, Forseti — Stealth imaging with 4C OBC seismic: EAGE/SEG Research Workshop, Extended Abstracts, A21. Rogno, H., A. Kristensen, and L. Amundsen, 1999, The Statfjord 3D, 4-C OBC survey: The Leading Edge, 18, 1301–1305. Rosland, B. O., E. L. Tree, and O. I. Barkved, 1999, Acquisition of 3D/4C OBS data at Valhall: 61st Annual Conference and Exhibition, EAGE, Extended Abstracts, 6–17. Stewart, S. A., and R. J. Davies, 2006, Structure and emplacement of mud volcano systems in the South Caspian Basin: AAPG Bulletin, 90, 771–786. Stewart, J., A. Shatilo, C. Jing, T. Rape, R. Duren, K. Lewallen, and G. Szurek, 2004, A comparison of streamer and OBC seismic data at Beryl Alpha field, U. K. North Sea: Geophysics, 72, no. 3, B69–B80. 4270 SEG Houston 2009 International Exposition and Annual Meeting

As the world's social-environmental problems increasingly extend across boundaries, both disciplinary and political, there is a growing need for interdisciplinarity, not only in research per se, but also in doctoral education. We present the common pitfalls of interdisciplinary research in doctoral education, illustrating approaches towards solutions using the Nordic Centre for Research on Marine Ecosystems and Resources under Climate Change (NorMER) research network as a case study. We provide insights and detailed examples of how to overcome some of the challenges of conducting interdisciplinary research within doctoral studies that can be applied within any doctoral/postdoctoral education programme, and beyond. Results from a selfevaluation survey indicate that early-career workshops, annual meetings and research visits to other institutions were the most effective learning mechanisms, whereas single discipline-focused courses and coursework were among the least effective learning mechanisms. By identifying the strengths and weaknesses of components of NorMER, this case study can inform the design of future programmes to enhance interdisciplinarity in doctoral education, as well as be applied to science collaboration and academic research in general.

Coming Together for Climate and Health: Proceedings of the Second Annual Clinical Climate Change Meeting, January 24, 2020.

Abstract and case study poster sessions will be conducted during the College of American Pathologists' Annual Meeting (CAP '07), which is scheduled for September 30 to October 3, 2007. The meeting will occur at the Sheraton Chicago Hotel & Towers, Chicago, Ill. The poster sessions will occur in the Connection Café and Exhibit Hall. Specific dates and times for each poster session are listed below. Also shown below each poster session listing are the subject areas that will be presented during each session.

Back to table of contents Previous article Next article Annual MeetingFull AccessAnnual Meeting Panel to Examine the Evolution of Physician Aid in DyingMark MoranMark MoranSearch for more papers by this authorPublished Online:26 Feb 2023https://doi.org/10.1176/appi.pn.2023.03.3.26AbstractPanel members will discuss the challenge of defining standards for “irremediability” in psychiatric disorders and will discuss the impact of expanding laws regarding physician-assisted dying on marginalized populations suffering from life distress.Physician Aid in Dying (PAD), also known as Medical Aid in Dying (MAiD) has been legalized or decriminalized in over a dozen jurisdictions around the world, and assisted dying policies continue to evolve, including in the United States. Many jurisdictions are exploring whether to introduce PAD laws or expand existing law to include PAD based on a mental disorder.“The psychiatrist helping patients to consider this unique and permanent request has a responsibility to assess for potentially treatable contributing conditions, including demoralization,” says John Peteet, M.D.This year’s Annual Meeting in San Francisco will feature a panel discussion titled “Physician-Assisted Death and Psychiatric Disorders.” PAD for mental disorders has been permitted for two decades in the Netherlands and Belgium, and 2023 marks the legalization of the practice in Canada (to be introduced as of March 2023).John Peteet, M.D., will explore how capacity for PAD may differ from capacity to refuse treatment. He is an associate professor of psychiatry at Harvard Medical School and director of the psychosocial oncology and palliative care fellowship at the Dana-Farber Cancer Institute.“I plan to focus on the role of the psychiatrist in evaluating patients for capacity to request MAiD, which is a role we play in several U.S. jurisdictions now,” he told Psychiatric News. “I’ll be suggesting that rather than a straightforward assessment of depression and the intellectual understanding of what is involved, the psychiatrist as a physician helping patients to consider this unique and permanent request has a responsibility to assess for potentially treatable contributing conditions, including demoralization.”Case examples will illustrate that at stake is not only the patient’s cognitive capacity and DSM diagnosis, but also the patient’s emotional capacity and the professional and clinical responsibility of the doctor to the patient.K. Sonu Gaind, M.D., a professor of psychiatry at the University of Toronto and past president of the Canadian Psychiatric Association, will review the Canadian experience, as Canada moves toward providing MAiD for patients with psychiatric disorders. Gaind is on the Council of Canadian Academies Expert Panel reviewing PAD for mental disorders.Marie Nicolini, M.D., Ph.D., psychiatrist and researcher at the Belgian Research Foundation Flanders and Georgetown University, will discuss the history of PAD for patients with psychiatric disorders in the Netherlands and Belgium.Panel members will discuss the challenge of defining adequate standards for “irremediability” in psychiatric disorders and patient requests for PAD and discuss the potential impact of expanding PAD laws on marginalized populations suffering from life distress. ■ ISSUES NewArchived

Dear Editor, Over the last 5 months, the IFT Education Advisory Panel has been assessing ways to enhance the value of the IFT Annual Meeting & Food Expo for attendees from the academic community and others who are interested in excellence in teaching, learning, research, and extension/outreach. On November 9th, the Board of Directors approved the proposed recommendations for repositioning and enhancing what was formerly known as the “Education and Professional Development” track. This new, innovative design will be referred to as the Teaching & Learning SPA (Science Practice Application) Program. Utilizing insights gained from the responses to a survey that went to over 6100 food scientists, the Education Advisory Panel outlined 3 major components for the Teaching & Learning SPA Program: Interaction and time for informal discussions in the SPA Lounge. The SPA Lounge will be a gathering place open for the duration of the Annual Meeting and will serve many purposes, including networking with others interested in teaching and learning, including presenters and award winners, and participating in interactive sessions. New skill-building courses that will address topics on which food science educators are seeking information, such as best practices. A keynote speaker modeled after the Beacon Lecturer will speak on a topic connected to food science education. Following the lecture, an interactive workshop with the speaker will be offered to round out this half-day event and provide a deep dive into the materials presented. To help foster year-around learning, there is a plan to help collect teaching and learning resources (that is, sample curriculum, case studies) and promote research in JFSE. These will likely be collected within the Education Division's online community resource library. We hope these resources will help inspire programming at the Annual Meeting. Similarly, it is our intention that material presented at the Annual Meeting will be posted in this resource and/or will be written for publication in JFSE. To learn more about these recommendations, view the final report here. A workgroup is currently being appointed to ensure these recommendations are implemented at the 2013 Annual Meeting. If you have an idea for the Teaching & Learning SPA Program, or would like to be considered to help develop programming, please submit your name via instructions here. Sincerely yours,

The Pediatric Pharmacy Association and Members Threaded Through a Career and the Impact on Pediatric Drug Development.

Background: Tumor metabolism is the hallmark of cancer cells. Cancer cells utilize different nutrient sources to drive the metabolic pathways to sustain tumor growth. Glucose (Glu) and Glutamine (Gln) are the primary nutrient sources on which cancer cells thrive. Developing precision diet based on patient’s molecular characteristics can help treat the cancer with dietary modulations along with traditional approaches. Methods: Computational Biology Model (CBM) captures the signaling and metabolic pathways to predict cancer phenotypes and biomarkers. Genomic aberrations (Mutations / Copy Number Variations (CNV)) from a patient’s tumor are input into the CBM to create the patient disease model. CBM is used for diet prediction based on the molecular characteristics of the patient’s disease. CBM is validated using a data set of 54 cancer cell-lines across indications, by assessing nutrient dependency for Glu and Gln. Simulation based prediction of Glu and Gln dependency is based on the expression of transporters and rate limiting enzymes of cellular glucose (SLC2A1-4, HK2) and glutamine (SLC1A5, GLS) uptake. The enzymes regulating the de-novo synthesis of glucose (PCK1/2, FBP1) and glutamine (GLUL) are negative determinants. In the CBM, an index is defined to measure Glu and Gln dependency. Glu Dependency Index = (SLC2A1 + SLC2A2 + SLC2A3 + SLC2A4 + HK2) / (PCK1 + PCK2) Gln Dependency Index = (SLC1A5 + GLS) / (GLUL) Threshold values for Glu and Gln dependency was determined based on the simulation correlation with the cell-line data. The validated CBM was then used for diet prediction for patient genomics. Results: Validation of genomics-based diet prediction by CBM using 54 cancer cell lines had an accuracy, positive predictive value and negative predictive value of 85%, 97% and 44% for Glu dependency and 82%, 94% and 50% for Gln dependency respectively. Using this validated CBM, we present predictions of patient nutrient source dependency based on their tumor genomics: Case Study 1: A Glioblastoma multiforme (GBM) patient case with PTEN EGFRVIII and ALK mutation and high copy number of HIF1A and MIR-145. CBM predicted the patient to be Glu dependent and Gln independent. Case Study 2: A GBM patient case with CTNNB1 mutation and low copy number of PTEN, RB1 and NF1. This patient was predicted to be both Glu and Gln dependent. Case Study 3: A Triple Negative Breast Cancer (TNBC) patient carrying mutations for MYC, BRD4, EP300 and CREBBP. CBM predicted this patient to be Gln dependent and Glu independent. The rationales for the nutrient source dependency predictions based on disease pathway characteristics were determined. Conclusion: Using CBM we could successfully use patient genomic data to predict nutrient dependency of patient’s tumor. This analysis enables creating options for precision diet for a patient to be used as an adjuvant alongside traditional approaches. Citation Format: Shireen Vali, Taher Abbasi, Subrat Mohapatra, Vishwas Joseph, Ashish Kumar Agrawal, Anuj Tyagi, Neelesh Lunkad, Ashokraja Balla. Computational biology model (CBM) predicts nutrient dependency of cancer patients based on Tumor Genomics: Implication of precision diet in cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1843.