Abstract TP257: Association Of Depressive Symptoms, Carotid Stenosis And The Co-occurrence Of Both With Inflammatory Markers In An Elderly Panamanian Cohort

Abstract

Objective: The relationship between depressive symptoms (DS) and carotid stenosis (CS) in elderly individuals has received a lot of attention recently, with conflicting results. Attempts to look for several serum inflammatory markers that could correlate with both conditions have also been made, mainly in Caucasian population. The purpose of this study is to examine associations between DS, CS, and seven inflammatory markers in an elderly Panamanian cohort. Methods: A sample of 136 elder individuals underwent Doppler sonography to estimate the presence of CS. DS were assessed with the 30-item Geriatric Depression Scale (GDS-30). Blood samples were obtained and the following inflammatory markers were determined: Beta-2 microglobulin (B2M), fatty acid-binding protein (FABP), factor VII (FVII), I-309, intercellular adhesion molecule-1 (ICAM-1), thymus and activation-regulated chemokine (TARC), and pancreatic polypeptide (PP). Analyses of the relationship between functional abilities and biomarkers across different groups were conducted using multivariate analyses of covariance. Results: Participants with DS conserved fewer activities of daily living (ADL) abilities (p<0.000), had higher levels of B2M (p<0.000) and decreased levels of FABP (p=0.009). Patients with CS conserved fewer ADL abilities (p<0.000) and had higher levels of B2M (p=0.001). Subjects with DS and CS conserved fewer ADL abilities (p<0.000), had increased levels of B2M (p<0.000), and ICAM-1 (p=0.46). There were no significant multivariate effects for years of education, I-309, PP, factor VII, and TARC. Conclusions: In the present study, it was found that DS were associated with lower ADL abilities, increased levels of B2M, and decreased levels of FABP. CS was associated with lower ADL abilities and increased B2M, and significant associations were observed with the co-occurrence of CS and DS with lower ADL abilities, increased levels of B2M and ICAM-1. The implications of these significant effects could be pointing in the direction that inflammation may considerably modulate the association between CS and DS in non-Caucasian population.