Abstract TP203: Serum Uric Acid is Associated With Arterial Stiffness, Pulse Pressure and Stroke in Apparently Healthy Population

Abstract

Introduction: Serum uric acid has been reported to be associated with arterial stiffness and cardiovascular disease in previous studies. However, some of them showed contradicting results. Also, some studies reported gender difference in the association between uric acid and vascular disease. We investigated whether serum uric acid is associated with arterial stiffness, blood pressure, and stroke in both genders. Methods: A total of 54,164 subjects who underwent health check-ups including brachial-ankle pulse weave velocity (baPWV) between 2004 and 2015 were enrolled. The average of the baPWV values obtained on both sides was used for further analysis. Past medical history was investigated through interview. Multivariable linear and logistic regression were used for the evaluation of association between serum uric acid and vascular outcomes. Results: Mean age was 45 ± 12 and male was 45,941 (85%). History of hypertension was in 10,278 (19%) and stroke in 460 (0.9%). Systolic blood pressure was 118 ±13 and diastolic blood pressure was 75 ± 9. baPWV was 1387 ± 223 cm/s. On multivariable linear regression, serum uric acid was associated with baPWV (beta 14.1; 95% CI 9.45 - 18.8), systolic blood pressure (beta 0.82; 95% CI 0.50 - 1.15), diastolic blood pressure (beta 0.57; 95% CI 0.34 - 0.80), and pulse pressure (beta 0.25; 95% CI 0.04 - 0.47). When we performed the same analyses in population without hypertension and stroke, the results did not change. On multivariable logistic regression, serum uric acid was associated with hypertension (odds ratio 1.42; 95% CI 1.33 - 1.51) and stroke (odds ratio 1.30; 95% CI 1.03 - 1.63). Conclusion: We showed that serum uric acid is significantly associated with arterial stiffness, various measures of blood pressure, hypertension and stroke in this single large cohort, irrespective of gender.